{"id":2786,"date":"2024-12-12T13:10:07","date_gmt":"2024-12-12T16:10:07","guid":{"rendered":"https:\/\/sites.icb.ufmg.br\/labnano\/?p=2786"},"modified":"2024-12-12T13:18:30","modified_gmt":"2024-12-12T16:18:30","slug":"pesquisadores-criam-plataforma-de-vacina-de-covid-que-pode-ser-adaptada-e-usada-contra-outras-doencas-entenda","status":"publish","type":"post","link":"https:\/\/sites.icb.ufmg.br\/labnano\/pesquisadores-criam-plataforma-de-vacina-de-covid-que-pode-ser-adaptada-e-usada-contra-outras-doencas-entenda\/","title":{"rendered":"Pesquisadores criam plataforma de vacina de Covid que pode ser adaptada e usada contra outras doen\u00e7as; entenda"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2786\" class=\"elementor elementor-2786\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d9f6447 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d9f6447\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-062a36f\" data-id=\"062a36f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2047ceb elementor-widget elementor-widget-heading\" data-id=\"2047ceb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pesquisadores criam plataforma de vacina de Covid que pode ser adaptada e usada contra outras doen\u00e7as; entenda<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c10a9f2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c10a9f2\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-83a3994\" data-id=\"83a3994\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-384ce88 hfe-post-info-layout-inline elementor-widget elementor-widget-post-info-widget\" data-id=\"384ce88\" data-element_type=\"widget\" data-widget_type=\"post-info-widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"hfe-post-info-inline hfe-post-info-items hfe-post-info\">\n\t\t\t\t\t<li class=\"hfe-post-info-item elementor-repeater-item-8670954 hfe-post-info-inline-item\" itemprop=\"datePublished\"> \n\t\t\t\t\t\t\t<a href=\"https:\/\/sites.icb.ufmg.br\/labnano\/2024\/12\/12\/\">\n\t\t\t\n\t\t\t\t\t\t<span class=\"hfe-post-info-icon\">\n\t\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-calendar-alt\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"hfe-post-info-text hfe-post-info__item hfe-post-info__item--type-date\">\n\t\t\t\n\t\t\t\t\t\t\tdezembro 12, 2024\t\t\t\t\t<\/span>\n\t\t\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/li>\n\t\t\t\t<li class=\"hfe-post-info-item elementor-repeater-item-f639b23 hfe-post-info-inline-item\"> \n\t\t\t\n\t\t\t\t\t\t<span class=\"hfe-post-info-icon\">\n\t\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-clock\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<span class=\"hfe-post-info-text hfe-post-info__item hfe-post-info__item--type-time\">\n\t\t\t\n\t\t\t\t\t\t\t1:10 pm\t\t\t\t\t<\/span>\n\t\t\n\t\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2d58c36 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2d58c36\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3b6251c\" data-id=\"3b6251c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-79f4979 elementor-widget elementor-widget-image\" data-id=\"79f4979\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"530\" src=\"https:\/\/sites.icb.ufmg.br\/labnano\/wp-content\/uploads\/2024\/12\/DDDDQ-1.webp\" class=\"attachment-large size-large wp-image-2793\" alt=\"\" srcset=\"https:\/\/sites.icb.ufmg.br\/labnano\/wp-content\/uploads\/2024\/12\/DDDDQ-1.webp 984w, https:\/\/sites.icb.ufmg.br\/labnano\/wp-content\/uploads\/2024\/12\/DDDDQ-1-300x199.webp 300w, https:\/\/sites.icb.ufmg.br\/labnano\/wp-content\/uploads\/2024\/12\/DDDDQ-1-768x509.webp 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a25d8b7 elementor-widget elementor-widget-text-editor\" data-id=\"a25d8b7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><em>Vacina contra Covid-1* \u2014 Foto: PMM\/Divulga\u00e7\u00e3o<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fd2fd42 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fd2fd42\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f87ca8f\" data-id=\"f87ca8f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0227a42 elementor-widget elementor-widget-text-editor\" data-id=\"0227a42\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div id=\"chunk-ffirb\"><div class=\"mc-column content-text active-extra-styles \" data-block-type=\"unstyled\" data-block-weight=\"46\" data-block-id=\"2\"><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\">Pesquisadores da\u00a0<a class=\"\" href=\"https:\/\/g1.globo.com\/educacao\/universidade\/ufmg\/\" data-mrf-link=\"https:\/\/g1.globo.com\/educacao\/universidade\/ufmg\/\">Universidade Federal de Minas Gerais<\/a>\u00a0(UFMG) desenvolveram uma plataforma de imuniza\u00e7\u00e3o contra variantes da Covid-19. A tecnologia, baseada em DNA encapsulado em nanopart\u00edculas lip\u00eddicas,\u00a0<span class=\"highlight highlighted\">j\u00e1 teve a efic\u00e1cia comprovada em testes realizados em animais e, agora, est\u00e1 sendo adaptada para atuar contra a chikungunya<\/span>.<\/p><\/div><\/div><div class=\"wall protected-content\"><div id=\"chunk-alk9p\"><div class=\"mc-column content-text active-extra-styles \" data-block-type=\"unstyled\" data-block-weight=\"52\" data-block-id=\"4\"><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\">No caso da Covid,\u00a0<span class=\"highlight highlighted\">a ideia \u00e9 produzir uma vacina de DNA<\/span>, que, segundo o professor Pedro Pires Goulart Guimar\u00e3es, do Departamento de Fisiologia e Biof\u00edsica do Instituto de Ci\u00eancias Biol\u00f3gicas (ICB) da UFMG,\u00a0<span class=\"highlight highlighted\">\u00e9 mais est\u00e1vel e tem custo menor do que as de RNA<\/span>, como as Pfizer e da Moderna.<\/p><\/div><\/div><div id=\"chunk-ec16u\"><div class=\"mc-column content-text active-extra-styles \" data-block-type=\"unstyled\" data-block-weight=\"34\" data-block-id=\"5\"><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\">\ud83e\uddea Para que o RNA e o DNA entrem na c\u00e9lula e resultem na produ\u00e7\u00e3o de ant\u00edgenos, eles s\u00e3o encapsulados em nanopart\u00edculas lip\u00eddicas \u2013 sistemas de libera\u00e7\u00e3o de f\u00e1rmacos de maneira controlada no organismo.<\/p><div id=\"chunk-fbqec\"><div class=\"mc-column content-text active-extra-styles \" data-block-type=\"unstyled\" data-block-weight=\"18\" data-block-id=\"7\"><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\">\ud83e\uddea Os pesquisadores, ent\u00e3o, desenvolveram diferentes formula\u00e7\u00f5es de nanopart\u00edculas, em busca da que garantisse maior efic\u00e1cia de imuniza\u00e7\u00e3o.<\/p><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\"><span style=\"font-style: italic;\">&#8220;N\u00f3s produzimos dezenas de nanopart\u00edculas diferentes e usamos triagem in vivo. Usando um \u00fanico animal, conseguimos testar dezenas de formula\u00e7\u00f5es diferentes. Fizemos nanopart\u00edculas com 36 formula\u00e7\u00f5es diferentes, injetamos todas juntas no mesmo animal e, depois, vimos qual foi a melhor&#8221;, explicou o professor Pedro Guimar\u00e3es.<\/span><\/p><\/div><\/div><div id=\"chunk-9s232\"><div class=\"mc-column content-text active-extra-styles \" data-block-type=\"unstyled\" data-block-weight=\"28\" data-block-id=\"9\"><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\">O imunizante\u00a0<span class=\"highlight highlighted\">passou por testes pr\u00e9-cl\u00ednicos em hamsters e camundongos<\/span>. Os bichos receberam duas doses, com intervalo de 21 dias entre elas, e o in\u00f3culo letal do coronav\u00edrus.<\/p><\/div><\/div><div id=\"chunk-e8qt7\"><div class=\"mc-column content-text active-extra-styles \" data-block-type=\"unstyled\" data-block-weight=\"18\" data-block-id=\"10\"><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\">Os\u00a0<span class=\"highlight highlighted\">resultados indicaram efic\u00e1cia e imunogenicidade da vacina<\/span> e foram publicados na revista cient\u00edfica &#8220;Nature Communications&#8221; de janeiro.<\/p><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\"><span style=\"font-style: italic;\">&#8220;A nossa vacina induziu efic\u00e1cia e imunogenicidade semelhante \u00e0 da Pfizer, protegeu tamb\u00e9m contra variantes de Covid. A gente v\u00ea que a carga viral est\u00e1 reduzida nos animais vacinados, e os animais vacinados n\u00e3o morrem&#8221;, disse o professor.<\/span><\/p><\/div><\/div><div id=\"chunk-9ec4\"><div class=\"mc-column content-text active-extra-styles \" data-block-type=\"unstyled\" data-block-weight=\"37\" data-block-id=\"12\"><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\">Apesar do sucesso dos resultados em animais,\u00a0<span class=\"highlight highlighted\">n\u00e3o h\u00e1, at\u00e9 o momento, previs\u00e3o para a realiza\u00e7\u00e3o de testes da vacina em humanos<\/span>. Para isso, s\u00e3o necess\u00e1rias mais pesquisas e aprova\u00e7\u00e3o da Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria (Anvisa).<\/p><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\"><span style=\"font-style: italic;\">&#8220;Isso envolve vontade pol\u00edtica, porque tem custos altos. O teste cl\u00ednico tem custos elevados&#8221;, afirmou Pedro Guimar\u00e3es.<\/span><\/p><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\"><strong><span style=\"font-style: italic;\">Outras doen\u00e7as<\/span><\/strong><\/p><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\"><span style=\"font-style: italic;\">Ap\u00f3s os resultados indicarem efic\u00e1cia do imunizante contra a Covid-19,\u00a0<\/span><span class=\"highlight highlighted\" style=\"font-style: italic;\">os pesquisadores t\u00eam um novo alvo: a chikungunya<\/span><span style=\"font-style: italic;\">.<\/span><\/p><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\"><span style=\"font-style: italic;\">A ideia \u00e9 que\u00a0<\/span><span class=\"highlight highlighted\" style=\"font-style: italic;\">a plataforma de nanopart\u00edculas lip\u00eddicas seja utilizada no desenvolvimento de vacinas contra essa e outras doen\u00e7as<\/span><span style=\"font-style: italic;\">, reduzindo o tempo e os custos envolvidos no processo.<\/span><\/p><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\"><span style=\"font-style: italic;\">&#8220;N\u00f3s testamos e validamos essa plataforma contra a Covid, mas agora j\u00e1 temos uma nanopart\u00edcula que entrega muito para o \u00f3rg\u00e3o linfoide, que vai construir a imunidade contra a doen\u00e7a. Para pensarmos vacinas para dengue ou chikungunya, \u00e9 s\u00f3 mudar o DNA ou o RNA que est\u00e1 ali dentro, a plataforma j\u00e1 est\u00e1 constru\u00edda&#8221;, explicou o professor.<\/span><\/p><\/div><\/div><div id=\"chunk-arcdf\"><div class=\"mc-column content-text active-extra-styles\" data-block-type=\"raw\" data-block-weight=\"17\" data-block-id=\"13\"><blockquote><div id=\"chunk-8oajo\"><div class=\"mc-column content-text active-extra-styles\" data-block-type=\"raw\" data-block-weight=\"15\" data-block-id=\"19\">\u00a0<\/div><\/div><div id=\"chunk-3su39\"><div class=\"mc-column content-text active-extra-styles \" data-block-type=\"unstyled\" data-block-weight=\"26\" data-block-id=\"20\"><p class=\" content-text__container \" data-track-category=\"Link no Texto\" data-track-links=\"\" data-mrf-recirculation=\"Artigo - Links Texto\">\u00a0<\/p><\/div><\/div><\/blockquote><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Pesquisadores criam plataforma de vacina de Covid que pode ser adaptada e usada contra outras doen\u00e7as; entenda dezembro 12, 2024 1:10 pm Vacina contra Covid-1* \u2014 Foto: PMM\/Divulga\u00e7\u00e3o Pesquisadores da\u00a0Universidade Federal de Minas Gerais\u00a0(UFMG) desenvolveram uma plataforma de imuniza\u00e7\u00e3o contra variantes da Covid-19. A tecnologia, baseada em DNA encapsulado em nanopart\u00edculas lip\u00eddicas,\u00a0j\u00e1 teve a efic\u00e1cia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2787,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-2786","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-educacao-e-pesquisa"],"_links":{"self":[{"href":"https:\/\/sites.icb.ufmg.br\/labnano\/wp-json\/wp\/v2\/posts\/2786","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.icb.ufmg.br\/labnano\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.icb.ufmg.br\/labnano\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.icb.ufmg.br\/labnano\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.icb.ufmg.br\/labnano\/wp-json\/wp\/v2\/comments?post=2786"}],"version-history":[{"count":10,"href":"https:\/\/sites.icb.ufmg.br\/labnano\/wp-json\/wp\/v2\/posts\/2786\/revisions"}],"predecessor-version":[{"id":2799,"href":"https:\/\/sites.icb.ufmg.br\/labnano\/wp-json\/wp\/v2\/posts\/2786\/revisions\/2799"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.icb.ufmg.br\/labnano\/wp-json\/wp\/v2\/media\/2787"}],"wp:attachment":[{"href":"https:\/\/sites.icb.ufmg.br\/labnano\/wp-json\/wp\/v2\/media?parent=2786"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.icb.ufmg.br\/labnano\/wp-json\/wp\/v2\/categories?post=2786"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.icb.ufmg.br\/labnano\/wp-json\/wp\/v2\/tags?post=2786"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}