Vivian Vasconcelos Costa
http://lattes.cnpq.br/6010924145549202
Áreas de pesquisa :
Tem experiência nas áreas de Microbiologia, Biologia celular e Imunologia, com ênfase em imunologia celular, virologia e interação microrganismo- hospedeiro atuando principalmente nos seguintes temas: imunopatologia da infecção pelos vírus da dengue, Chikungunha, Mayaro, Febre amarela e Zika; artrites virais e auto-imunes, com ênfase no desenvolvimento de modelos experimentais (incluindo modelo humanizado) para estudo da patogênese e teste de terapias.
Produtos, Patentes e Publicações relevantes
In-depth characterization of congenital Zika syndrome in immunocompetent mice: Antibody- dependent enhancement and an antiviral peptide therapy. EBioMedicine. 2019 Jun;44:516-529. doi: 10.1016/j.ebiom.2019.05.014.
Pluripotency of Wolbachia against Arboviruses: the case of yellow fever. Gates Open Res. 2019 Apr 16;3:161. doi: 10.12688/gatesopenres.12903.2.
Host Immune Response to ZIKV in an Immunocompetent Embryonic Mouse Model of Intravaginal Infection. Viruses. 2019 Jun 17;11(6). pii: E558. doi: 10.3390/v11060558.
Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses. Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00397-19. doi: 10.1128/AAC.00397-19.
Animal model of arthritis and myositis induced by the Mayaro virus. PLoS Negl Trop Dis. 2019 May 3;13(5):e0007375. doi: 10.1371/journal.pntd.0007375.
Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo. PLoS Negl Trop Dis. 2019 Jan 30;13(1):e0007072. doi: 10.1371/journal.pntd.0007072.
Evidence of natural Zika virus infection in neotropical non-human primates in Brazil. Sci Rep. 2018 Oct 30;8(1):16034. doi: 10.1038/s41598-018-34423-6.
Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide. Nat Mater. 2018 Nov;17(11):971-977. doi: 10.1038/s41563-018-0194-2.
Host target-based approaches against arboviral diseases. Biol Chem. 2018 Feb 23;399(3):203- 217. doi: 10.1515/hsz-2017-0236. Review.
Zika Virus Promotes Neuronal Cell Death in a Non-Cell Autonomous Manner by Triggering the Release of Neurotoxic Factors. Front Immunol. 2017 Aug 23;8:1016. doi: 10.3389/fimmu.2017.01016.
Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules. mBio. 2017 Aug 1;8(4). pii: e00741-17. doi: 10.1128/mBio.00741-17.
Serum Metabolomics Investigation of Humanized Mouse Model of Dengue Virus Infection. J Virol. 2017 Jun 26;91(14). pii: e00386-17. doi: 10.1128/JVI.00386-17.
N-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection. mBio. 2017 Apr 25;8(2). pii: e00350-17. doi: 10.1128/mBio.00350-17.
Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study. PLoS Negl Trop Dis. 2017 Feb 23;11(2):e0005363. doi: 10.1371/journal.pntd.0005363.
E-mail: vivianvcosta @icb.ufmg.br
Áreas de pesquisa :
Tem experiência nas áreas de Microbiologia, Biologia celular e Imunologia, com ênfase em imunologia celular, virologia e interação microrganismo- hospedeiro atuando principalmente nos seguintes temas: imunopatologia da infecção pelos vírus da dengue, Chikungunha, Mayaro, Febre amarela e Zika; artrites virais e auto-imunes, com ênfase no desenvolvimento de modelos experimentais (incluindo modelo humanizado) para estudo da patogênese e teste de terapias.
Produtos, Patentes e Publicações relevantes
In-depth characterization of congenital Zika syndrome in immunocompetent mice: Antibody- dependent enhancement and an antiviral peptide therapy. EBioMedicine. 2019 Jun;44:516-529. doi: 10.1016/j.ebiom.2019.05.014.
Pluripotency of Wolbachia against Arboviruses: the case of yellow fever. Gates Open Res. 2019 Apr 16;3:161. doi: 10.12688/gatesopenres.12903.2.
Host Immune Response to ZIKV in an Immunocompetent Embryonic Mouse Model of Intravaginal Infection. Viruses. 2019 Jun 17;11(6). pii: E558. doi: 10.3390/v11060558.
Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses. Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00397-19. doi: 10.1128/AAC.00397-19.
Animal model of arthritis and myositis induced by the Mayaro virus. PLoS Negl Trop Dis. 2019 May 3;13(5):e0007375. doi: 10.1371/journal.pntd.0007375.
Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo. PLoS Negl Trop Dis. 2019 Jan 30;13(1):e0007072. doi: 10.1371/journal.pntd.0007072.
Evidence of natural Zika virus infection in neotropical non-human primates in Brazil. Sci Rep. 2018 Oct 30;8(1):16034. doi: 10.1038/s41598-018-34423-6.
Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide. Nat Mater. 2018 Nov;17(11):971-977. doi: 10.1038/s41563-018-0194-2.
Host target-based approaches against arboviral diseases. Biol Chem. 2018 Feb 23;399(3):203- 217. doi: 10.1515/hsz-2017-0236. Review.
Zika Virus Promotes Neuronal Cell Death in a Non-Cell Autonomous Manner by Triggering the Release of Neurotoxic Factors. Front Immunol. 2017 Aug 23;8:1016. doi: 10.3389/fimmu.2017.01016.
Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules. mBio. 2017 Aug 1;8(4). pii: e00741-17. doi: 10.1128/mBio.00741-17.
Serum Metabolomics Investigation of Humanized Mouse Model of Dengue Virus Infection. J Virol. 2017 Jun 26;91(14). pii: e00386-17. doi: 10.1128/JVI.00386-17.
N-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection. mBio. 2017 Apr 25;8(2). pii: e00350-17. doi: 10.1128/mBio.00350-17.
Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study. PLoS Negl Trop Dis. 2017 Feb 23;11(2):e0005363. doi: 10.1371/journal.pntd.0005363.
E-mail: vivianvcosta @icb.ufmg.br