{"id":523,"date":"2023-11-03T17:16:23","date_gmt":"2023-11-03T20:16:23","guid":{"rendered":"https:\/\/neurobioquimica-com.umbler.net\/?p=523"},"modified":"2023-11-12T22:01:51","modified_gmt":"2023-11-13T01:01:51","slug":"os-microrganismos-influenciam-na-depressao","status":"publish","type":"post","link":"https:\/\/sites.icb.ufmg.br\/neurobioquimica\/os-microrganismos-influenciam-na-depressao\/","title":{"rendered":"Os microrganismos influenciam na depress\u00e3o?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"523\" class=\"elementor elementor-523\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ba63ec9 e-flex e-con-boxed e-con e-parent\" data-id=\"ba63ec9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fb8223b e-flex e-con-boxed e-con e-parent\" data-id=\"fb8223b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0a20ff4 elementor-widget elementor-widget-spacer\" data-id=\"0a20ff4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4e3b6a2 e-flex e-con-boxed e-con e-parent\" data-id=\"4e3b6a2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f9043a elementor-widget elementor-widget-heading\" data-id=\"7f9043a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Os microorganismos influenciam na drepess\u00e3o?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b555137 elementor-widget elementor-widget-text-editor\" data-id=\"b555137\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">\u00c9 fato que possu\u00edmos uma &#8220;microbiota&#8221;, mas o que isso significa e como ela nos afeta? Chamamos de &#8220;microbiota&#8221; o conjunto de microrganismos que habitam um ambiente espec\u00edfico. Surpreendentemente, nosso intestino abriga uma enorme quantidade de microrganismos, e em nosso corpo, existem mais microrganismos do que c\u00e9lulas pr\u00f3prias!<\/span><\/p><p><span style=\"font-weight: 400;\">Hoje, j\u00e1 sabemos que esses microrganismos desempenham um papel fundamental na regula\u00e7\u00e3o de diversas fun\u00e7\u00f5es fisiol\u00f3gicas. Eles exercem influ\u00eancia sobre o metabolismo, o sistema imunol\u00f3gico, o sistema end\u00f3crino e muito mais. Quando ocorre um desequil\u00edbrio na microbiota, surge o que chamamos de &#8220;disbiose&#8221;, um estado em que a sa\u00fade do hospedeiro, ou seja, n\u00f3s, seres humanos, pode ser prejudicada.<\/span><\/p><p><span style=\"font-weight: 400;\">Surpreendentemente, nosso sistema nervoso tamb\u00e9m pode ser afetado pela disbiose, principalmente devido \u00e0 conex\u00e3o conhecida como eixo intestino-c\u00e9rebro. Essa via de comunica\u00e7\u00e3o bidirecional entre o intestino e o sistema nervoso central resulta no fato de\u00a0 que as altera\u00e7\u00f5es na microbiota podem influenciar profundamente nossa sa\u00fade mental.<\/span><\/p><p><span style=\"font-weight: 400;\">Fatores como mudan\u00e7as abruptas na alimenta\u00e7\u00e3o, estresse e o uso de certos medicamentos, por exemplo, podem desencadear a disbiose, levando \u00e0 altera\u00e7\u00e3o da permeabilidade intestinal. Isso, por sua vez, permite a entrada de toxinas e fragmentos bacterianos para a corrente sangu\u00ednea. Essa situa\u00e7\u00e3o pode, de fato, desencadear uma resposta inflamat\u00f3ria sist\u00eamica e causar problemas de sa\u00fade. A mudan\u00e7a na permeabilidade tamb\u00e9m pode prejudicar a absor\u00e7\u00e3o de nutrientes essenciais para o corpo e, por exemplo, interferir na s\u00edntese e disponibilidade de serotonina, o que pode levar a quadros de depress\u00e3o.<\/span><\/p><p><span style=\"font-weight: 400;\">Al\u00e9m disso, altera\u00e7\u00f5es na composi\u00e7\u00e3o das esp\u00e9cies da microbiota normal podem ter consequ\u00eancias significativas. Estudos apontam que a aus\u00eancia de certas bact\u00e9rias, como <\/span><i><span style=\"font-weight: 400;\">Faecalibacterium spp.<\/span><\/i><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Coprococcus spp.<\/span><\/i><span style=\"font-weight: 400;\"> e <\/span><i><span style=\"font-weight: 400;\">Dialister spp.<\/span><\/i><span style=\"font-weight: 400;\">, pode estar relacionada a um aumento da inflama\u00e7\u00e3o e a uma redu\u00e7\u00e3o na sa\u00fade mental, contribuindo para doen\u00e7as como a depress\u00e3o. Em pesquisas recentes, foi observado que mesmo pacientes em tratamento com antidepressivos apresentavam falta dessas bact\u00e9rias em sua microbiota. Portanto, sim! Os microrganismos podem influenciar, e muito, n\u00e3o apenas na depress\u00e3o, mas tamb\u00e9m na ansiedade e doen\u00e7as neurodegenerativas.<\/span><\/p><p><span style=\"font-weight: 400;\">\u00a0<\/span><\/p><p><b>Refer\u00eancias:<\/b><\/p><p><span style=\"font-weight: 400;\">VALLES-COLOMER, M., FALONY, G., DARZI, Y. et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nature Microbiology, 623\u2013632, Fevereiro, 2019.<\/span><\/p><p><span style=\"font-weight: 400;\">HAO, Zikai; WANG, Wei; GUO, Rong; et al. Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats. Elsevier, v. 104, p. 132-142, junho de 2019<\/span><\/p><p><span style=\"font-weight: 400;\">SARAIVA, Fl\u00e1via R. S.; CARVALHO, Luiza M. F.; et al. Revis\u00e3o: depress\u00e3o e disbiose. UNIFISA, dezembro de 2019<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4be7b2d elementor-widget elementor-widget-spacer\" data-id=\"4be7b2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Os microorganismos influenciam na drepess\u00e3o? \u00c9 fato que possu\u00edmos uma &#8220;microbiota&#8221;, mas o que isso significa e como ela nos afeta? Chamamos de &#8220;microbiota&#8221; o conjunto de microrganismos que habitam um ambiente espec\u00edfico. Surpreendentemente, nosso intestino abriga uma enorme quantidade de microrganismos, e em nosso corpo, existem mais microrganismos do que c\u00e9lulas pr\u00f3prias! Hoje, j\u00e1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sem-categoria"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Os microrganismos influenciam na depress\u00e3o? - Laborat\u00f3rio Neurobioqu\u00edmica - Universidade Federal de Minas Gerais<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.icb.ufmg.br\/neurobioquimica\/os-microrganismos-influenciam-na-depressao\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Os microrganismos influenciam na depress\u00e3o? - Laborat\u00f3rio Neurobioqu\u00edmica - Universidade Federal de Minas Gerais\" \/>\n<meta property=\"og:description\" content=\"Os microorganismos influenciam na drepess\u00e3o? \u00c9 fato que possu\u00edmos uma &#8220;microbiota&#8221;, mas o que isso significa e como ela nos afeta? Chamamos de &#8220;microbiota&#8221; o conjunto de microrganismos que habitam um ambiente espec\u00edfico. Surpreendentemente, nosso intestino abriga uma enorme quantidade de microrganismos, e em nosso corpo, existem mais microrganismos do que c\u00e9lulas pr\u00f3prias! 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Chamamos de &#8220;microbiota&#8221; o conjunto de microrganismos que habitam um ambiente espec\u00edfico. Surpreendentemente, nosso intestino abriga uma enorme quantidade de microrganismos, e em nosso corpo, existem mais microrganismos do que c\u00e9lulas pr\u00f3prias! 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